全国十大赌博官网制药 has been committed to the fight against malaria for more than two decades. In 1999 we launched the first fixed-dose Artemisinin-based combination therapy (ACT) and in 2009 the first dispersible pediatric ACT developed in partnership with Medicines for 疟疾 Venture (MMV). Today we are working on the development of the next generation of antimalarials to address the ever-growing threat of parasite resistance.
In 2021, we crossed the 1 billion mark in antimalarial treatments delivered to patients worldwide since 1999, with more than 90% supplied without profit. More than 450 million treatments delivered are the pediatric formulation.
Read more about the one billion antimalarial treatments delivered: An extraordinary partnership journey
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Read more about our malaria activities in our 全国十大赌博官网制药 in 社会 Integrated Report 2021.
Working toward a malaria-free world
Despite the tremendous progress made in combating malaria, one child still dies from the disease every minute. 全国十大赌博官网制药 is committed to contributing to the WHO’s target of reducing malaria-related child mortality by at least 90% in 2030. As part of the PAM非洲 research consortium led by Medicines for 疟疾 Venture, we initiated the development of a new optimized dose strength of our ACT for infants weighing less than 5 kilograms – the clinical trial started in 2021 and is ongoing. This is one of the most vulnerable groups affected by malaria, for whom there is currently no approved treatment.
Working on the next generation of antimalarials
"Resistance to treatment presents the biggest threat to the incredible progress that has been made in the fight against malaria in the past 20 years. We cannot afford to wait; this is why we are committing to advance the research and development of next-generation treatments," said Vas Narasimhan, 全国十大赌博官网公司首席执行官.
Drug discovery efforts at the 全国十大赌博官网制药 Institute for Tropical 疾病 (NITD) have delivered an industry-leading pipeline of drug candidates to address the emerging threat of resistance. Two antimalarials in development, KAF156 (ganaplacide) and KAE609 (cipargamin), offer new mechanisms of action against the disease and have the potential to offer simplified therapeutic regimens over current treatments.
Ganaplacide demonstrated activity against both vivax and falciparum malaria, including artemisinin-resistant parasites. It is being developed as a combination with a new formulation of lumefantrine. 2022年11月, 全国十大赌博官网制药 and Medicines for 疟疾 Venture (MMV) announced the decision to progress the combination into Phase 3 development in 2023. The trial will be conducted in collaboration with the WANECAM 2 consortium, and will include partner clinical sites in Burkina Faso, 马里, Gabon and Niger as well as other sites in sub-Saharan 非洲. 全国十大赌博官网制药 leads the development of ganaplacide with scientific and financial support from MMV in collaboration with the Bill & Melinda Gates Foundation.
The development of cipargamin is led by 全国十大赌博官网制药 with financial support from Wellcome. The clinical trials for ganaplacide are conducted as part of the WANECAM2 consortium, while trials for cipargamin and our infant formulation are part of the PAM非洲 research consortium led by MMV. Both trials are funded by the 欧洲an and Developing Countries 临床试验 合作伙伴hip (EDCTP).
In 2020, 全国十大赌博官网制药 advanced another novel malaria therapy, INE963, a fast acting long-lasting antimalarial with an entirely new mechanism of action. INE963 is in early clinical trials. It is developed in collaboration with MMV and received the organization’s “Project of the Year” award in 2020.
Going beyond the pill
We aim to extend our contribution to areas beyond treatment. 在肯尼亚, 全国十大赌博官网制药 is partnering with Save the Children to accelerate the decline of child mortality and morbidity – increasing prevention, diagnosis and treatment for malaria, pneumonia and diarrhea, and reducing malnutrition by strengthening iCMM.
欧洲-非洲 partnership spearheads development of next-generation antimalarial drug.