恰加斯病, 也被称为美洲锥虫病, is a potentially life-threatening illness caused by the protozoan parasite 鲁兹锥体1.
这种疾病影响了大约600万人1，主要在拉丁美洲. Less than 1% of affected individuals receive proper treatment2, and current available drugs have high rates of adverse effects and do not meet the need for the entire spectrum of the disease. 恰加斯病 usually begins with a bite by the triatomine bug, also known as the “kissing bug” because it usually bites people’s faces when they sleep. 人们常常在没有注意到的情况下被感染.
的 disease sits at the crossroads between two worlds: it starts as a tropical parasitic disease but can end as a chronic disease. 这就是为什么预防, treating and managing 恰加斯病 requires an integrated, end-to-end approach that covers both the acute and chronic phases.
Improving health outcomes for Chagas patients also requires being active on three fronts: novel drug discovery, 临床开发, 加强医疗体系.
的 全国十大赌博官网热带疾病研究所(NITD) and partners are discovering novel parasite-specific growth inhibitors for the treatment of 恰加斯病 and other kinetoplastid diseases. 的se efforts have identified unique drug targets in trypanosomatid parasitic protozoa that include proteosomes, CDC-like激酶, 和拓扑异构酶. A drug candidate to address chronic 恰加斯病 is now in early-stage clinical trials.
在慢性阶段, 当疾病发展时, 它可以影响心脏等关键器官, leading to cardiac disorders in up to 30% of patients and up to 10% may develop neurological and/or gastrointestinal disorders. Chagas cardiomyopathy accounts for the majority of death and disability among individuals affected by the disease. 在这样的背景下, in 2019, in collaboration with the Brazilian Clinical 研究 Institute, 全国十大赌博官网制药 launched the first clinical study in people with heart failure due to chronic Chagas cardiomyopathy to assess an innovative therapy in this underserved patient population. This Phase IV trial also includes sub-studies that may help better understand the underlying pathophysiology of Chagas cardiomyopathy (biomarkers, 心律失常的负担, and use of magnetic resonance imaging to evaluate cardiac structure, 功能与纤维化).
进一步, we are working with health authorities and stakeholders in Latin America on healthcare system strengthening initiatives to improve health outcomes and access to innovation. 例如, 全国十大赌博官网制药 signed a collaboration agreement with IS 全球 to improve the well-being of Chagas patients in Bolivia. 以长期可持续性为目标, 地方赋权和影响, the interventions are implemented in phases hand-in-hand with Bolivian and regional stakeholders. In 2022, 全国十大赌博官网参与了一个能力建设项目, 接触200多名医疗保健专业人员. We are also collaborating with the 全球恰加斯病联盟 to develop an online medical platform for 恰加斯病, which aims to build capability among healthcare professionals to adopt an integrated disease management approach.
We supported the World Heart Federation (WHF) and the Inter-American 社会 of Cardiology in developing an 恰加斯病端到端路线图，出版于2020年. It explores the patient journey from diagnosis to treatment, and provides actionable recommendations for policymakers and healthcare professionals. In 2022, under a research collaboration with the WHF and the Federal University of Minas Gerais in Brazil, we kicked off the RAISE study (的 buRden of ChAgas dISEase in the contemporary world) to assess the health and economic burden of 恰加斯病 globally.